Chemical-ionization mass spectrometry of .BETA.-lactam antibiotics.
نویسندگان
چکیده
منابع مشابه
Beta-Lactam Antibiotics and Vancomycin Beta-lactam antibiotics
Anti-bacterial drugs have “selective toxicity”, that is they interact with a target present on the bacterial cell, the prokaryote, that is not present in the mammalian host, the eukaryote. For the ß-lactam drugs, this target is the cell wall. Mammalian cells lack cell walls, which for the bacteria are a critically important barrier protecting the organism from not only the vagaries of osmotic s...
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Chemical ionization mass spectrometry, using isobutane as a reactant gas, is shown to be useful in the structural characterization of representative 16membered ring macrolide antibiotics. The spectra of spiramycin I, spiramycin III, and niddamycin contain relatively intense protonated molecule ion peaks (MH+) making establishment of molecular formulae straightforward. There are relatively few f...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1975
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.28.668